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Retatrutide (LY-3437943) is an experimental drug for obesity developed by the American pharmaceutical company Eli Lilly and Company. It is a triple glucagon hormone receptor agonist (GLP-1, GIP, and GCGR receptors). [1] .
Retatrutide works by activating the GIP, GLP-1, and glucagon receptors, combining their effects to regulate appetite and metabolism. This mechanism enhances satiety, suppresses hunger, and boosts energy expenditure through glucagon receptor stimulation.
By targeting three different hormone receptors involved in regulating blood sugar, appetite, and energy expenditure, Retatrutide shows promise in aiding weight loss and improving metabolic health.
Mar 3, 2025 · Early trials of retatrutide revealed that users could lose up to a quarter of their body weight in under a year, making it nearly twice as effective as Ozempic. Unlike other weight loss jabs, this drug not only reduces appetite but also speeds up metabolism, intensifying fat loss.
May 30, 2025 · Let’s find out -- the new GLP1 drug Retatrutide is a *triple* receptor agonist. So how's it going with Retatrutide? Well things are progressing quite nicely – some key research was …
Apr 4, 2025 · For the millions battling obesity and related health problems, retatrutide brings new hope. This triple-receptor agonist from Eli Lilly works on three metabolic pathways at once, …
Jan 3, 2025 · Answer: Retatrutide is an investigational peptide medication developed by Eli Lilly for the treatment of type 2 diabetes and obesity. It is designed as a multi-agonist targeting multiple hormone receptors involved in glucose regulation and appetite control.
Jun 26, 2023 · Retatrutide (LY3437943; Eli Lilly) is a single peptide conjugated to a fatty diacid moiety and has agonism toward the GIP, GLP-1, and GCG receptors.
Feb 1, 2024 · Retatrutide is a triple hormone (GIP, GLP-1 and glucagon) receptor agonist in development for the treatment of obesity. Obesity is a complex disease that occurs when an individual’s weight is higher than what is considered healthy for his/her height.
Jun 27, 2023 · Retatrutide is a glucagon-like peptide-1 (GLP-1) agonist, like Wegovy and Ozempic. But, while it works similarly to those drugs, it also acts on two additional hormones: glucose-dependent...
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